Recent Publications
1. Wei Hong, Zemin Wang, Wen Liu, Tiernan T. O’Malley, Ming Jin, Michael Willem, Christian Haass, Matthew P. Frosch, and Dominic M. Walsh (2018) Detection of high activity diffusible Aβ aggregates in Alzheimer’s disease brain. Acta Neuropathologica 136:19-40.
2. Ming Jin, Brian O’Nuallain, Wei Hong, Justin Boyd, Valentina N. Lagomarsino, Tiernan T. O’Malley, Wen Liu, Matthew P. Frosch, Tracy Young-Pearse, Dennis J. Selkoe, and Dominic M. Walsh (2018) An in vitro paradigm to assess anti-Aβ antibodies for Alzheimer’s disease. Nature Communications. 9(1):2676. doi: 10.1038/s41467-018-05068-w.
3. Neng-Wei Hu, Grant T. Corbett, Steven Moored, Igor Klyubina, Tiernan T. O’Malley, Dominic M. Walsh, Frederick J. Livesey, and Michael J. Rowan (2018) Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer’s Disease Disrupt Synaptic Plasticity. Cell Reports 23: 1932-1938.
4. Francesc X. Guix, Grant T. Corbett, Diana J. Cha, Maja Mustapic, Wen Liu, David Mengel, Zhicheng Chen, Elena Aikawa, Tracy Young-Pearse, Dimitrios Kapogiannis, Dennis J. Selkoe and Dominic M. Walsh (2018) Detection of Aggregation-competent Tau in neuron-derived extracellular vesicles. International Journal of Molecular Sciences. 19: E663-686.
5. Rachid El Fatimy, Shamin Li, Zhicheng Chen, Tashim Mushannen, Sree Gongala, Zhiun Wei, Darrick T. Balu, Rosalia Rabinovsky, Adam Cantlon, Abdullah Elkhal, Dennis J. Selkoe, Kai C. Sonntag, Dominic M. Walsh, Anna M Krichevsky (2018) MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathologica [Epub ahead of print]
6. Zemin Wang, Rosemary J. Jackson, Wei Hong, Walter M. Taylor, Grant T. Corbett, Arturo Moreno, Wen Liu, Shaomin Li, Matthew P. Frosch, Inna Slutsky, Tracy Young-Pearse, Tara L. Spires-Jones, and Dominic M. Walsh (2017) Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP. Journal of Neuroscience. 37: 11947-11966.
7. Ting Yang, Shaomin Li, Huixin Xu, Dominic M. Walsh and Dennis J. Selkoe (2017) Large soluble oligomers of amyloid β-protein from Alzheimer brain are far less neuroactive than the smaller oligomers to which they dissociate. Journal of Neuroscience 37: 152-163.
8. Tiernan T. O’Malley, William M. Witbold, Sara Linse and Dominic M. Walsh (2016) The aggregation paths and products of Aβ42 dimers are distinct from Aβ42 monomer. Biochemistry 55: 6150-6161.
9. Dainan Zhang, Alexandra J. Mably, Dominic M. Walsh and Michael J. Rowan (2017) Peripheral interventions indirectly enhancing brain glutamate homeostasis relieve amyloid ß- and TNFa-mediated synaptic plasticity disruption in the rat hippocampus. Cerebral Cortex 27: 3724-3735.
10. Alexandra J. Mably, Wen Liu, Jessica M. Mc Donald, Jean-Cosme Dodart, Frédérique Bard, Cynthia A. Lemere, Brian O’Nuallain and Dominic M. Walsh (2015) Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice. Neurobiology of Disease 82: 372-84.
11. Daniel Kanmert, Adam Cantlon, Christina R. Muratore, Ming Jin, Gloria Lee, Tracy L. Young-Pearse, Dennis J. Selkoe and Dominic M. Walsh (2015) C-terminally truncated forms of tau, but not full length tau or its C-terminal fragments, are released from neurons independent of cell death. Journal of Neuroscience 35:10851-65.
12. Adam Cantlon, Carlo Sala Frigerio, Darragh B. Freir, Barry Boland, Ming Jin, and Dominic M. Walsh (2015) The familial British dementia mutation promotes formation of neurotoxic cystine cross-linked ABri oligomers. Journal of Biological Chemistry 290:16502-16.
13. Olga Szczepankiewicz, Björn Linse, Georg Meisl, Eva Thulin, Birgitta Frohm, Carlo Sala Frigerio, Michael T. Colvin, Angela C. Jacavone, Robert G. Griffin, Tuomas Knowles, Dominic M. Walsh and Sara Linse (2015) N-terminal extensions retard Aβ42 fibril formation but allow cross-seeding and co-aggregation with Aβ42. Journal of the American Chemical Society 37:14673-85.
14. Jessica M. Mc Donald, Tiernan T. O’Malley, Wen Liu, Alexandra J. Mably, Gunnar Brinkmalm, Erik Portelius, William M. Wittbold, Matthew P. Frosch and Dominic M. Walsh (2015) The aqueous phase of Alzheimer’s disease brain contains assemblies built from ~4 and ~7 kDa Aβ species. Alzheimer’s Disease and Dementia 11: 1286-305.
15. Alexandra J. Mably, Daniel Kanmert, Jessica M. Mc Donald, Wen Liu, Barbara J. Caldarone, Cynthia A. Lemere, Brian O’Nuallain, Kenneth S. Kosik and Dominic M. Walsh (2015) Tau immunization: a cautionary tale? Neurobiology of Aging 36:1316-32.
16. Tiernan T. O’Malley, Nur Alia Oktaviani, Dainan Zhang, Aleksey Lomakin, Brian O’Nuallain, Sara Linse, George B. Benedek, Michael J. Rowan, Frans A. A. Mulder and Dominic M. Walsh (2014) Aβ dimers differ from monomers in structural propensity, aggregation paths, and population of synaptotoxic assemblies. Biochemical Journal 461: 413-426
Recent Reviews
1. Tiernan T. O’Malley and Dominic M. Walsh (2018) Lessons from the study of covalent dimers of the Alzheimer’s disease-associate amyloid β-protein. Biochemistry & Physiology. 7: 229-233. doi: 10.4172/2168-9652.1000229.
2. Dominic M. Walsh and Dennis J. Selkoe (2016) A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nature Neurosciene Reviews 17: 251-260.
3. Adam Cantlon, Carlo Sala Frigerio and Dominic M. Walsh (2015) Lessons from a rare dementia: amyloid and beyond. Journal of Parkinson’s disease and Alzheimer’s Disease. 2: 12-24.
Other Research Publications since 2004
1. Tiernan T. O’Malley, Sara Linse, Dominic M. Walsh (2018) Production and use of recombinant Aβ for aggregation studies. In, “Peptide Self-Assembly: Methods and Protocols”, Ed: T Doran and B Nelson, Humana Press, New York, NY. Methods in Molecular Biology 1777: pp307-320. doi: 10.1007/978-1-4939-7811-3_19.
2. Claire J. Sarell, Emma Quarterman, Daniel C-M Yip, Cassandra Terry, Andrew J. Nicol, Jonathan D. F. Wadsworth, Mark A. Farrow, Dominic M. Walsh and John Collinge (2017) Soluble Ab aggregates can inhibit prion propagation. Open Biology 7: 170158-69.
3. Kristopher Sarosiek, Cameron Fraser, Nathiya Muthalagu, Patrick D. Bhola, Weiting Chiang, Samual K. McBrayer, Adam Cantlon, Sudeshna Fisch, Gail Golomb-Mello, Jeremy Ryan, Jing Deng, Brian Jian, Chris Corbett, Marti Goldenberg, Joseph Madsen, Ronglih Liao, Dominic Walsh, John Sedivy, Daniel J. Murphy, Daniel Ruben Carrasco, Shenandoah Robinson, Javid Moslehi, Anthony Letai(2016) Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics. Cancer Cell pii: S1535-6108(16)30554-2.
4. Eleanor K. Pickett, Robert M. Koffie, Susanne Wegmann, Christopher Henstridge, Abigail G. Herrmann, Marti Colom-Cadena, Alberto Lleo, Kevin R. Kay, Melissa Vaught, Roy Soberman, Dominic M. Walsh, Bradley T. Hyman, and Tara L. Spires-Jones (2016) Non-fibrillar oligomeric amyloid-β within synapses. Journal of Alzheimer’s Disease 53: 787-800.
5. Ming Lei, Huixin Xu, Zhangyuan Li, Zemin Wang, Tiernan T. O’Malley, Dainan Zhang, Dominic M. Walsh, Pingyi Xu, Dennis J. Selkoe, Shaomin Li (2016) Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance. Neurobiology of Disease 85: 111-21.6
6. Colleen N. Loynachan, G Romero, MG. Christiansen, R Chen, R Ellison, Tiernan T. O’Malley, UP Froriep, Dominic M. Walsh, Polina Anikeeva (2015) Targeted magnetic nanoparticles for remote magnetothermal disruption of amyloid-β aggregates. Advances in Healthcare Materials doi: 10.1002/adhm.201500487.
7. Yinghua Guan, Kevin J. Cao, Adam Cantlon, Kristyna K. Elbel, Emmanuel A. Theodorakis, Dominic M. Walsh, Jerry Yang, Jagesh V. Shah (2015) Real-time monitoring of Alzheimer’s-related amyloid aggregation via Probe Enhancement Fluorescence Correlation Spectroscopy (PE–FCS). ACS Chem Neuroscience 6:1503-8.
8. James Keaney, Dominic M. Walsh, Tiernan O’Malley, Natalie Hudson, Darragh E. Crosbie, Teresa Loftus, Florike Sheehan, Marian M. Humphries, John J. Callanan, Francesca M. Brett, Michael A. Farrell, Peter Humphries and Matthew Campbell (2015) Passive paracellular diffusion of soluble amyloid-β across the blood-brain barrier. Science Advances; 1:e150047.
9. Monichan Phay, Alfred T. Welzel, Angela D. Williams, Helen P. McWilliams-Koeppen, Veronika Blinder, Tiernan T. O’Malley, Alan Solomon, Dominic M. Walsh, Brian O’Nuallain IgG conformer’s binding to amyloidogenic aggregates (2015) PLoS One 10(9):e0137344.
10. Yona Levites, Brian O’Nuallain, Rama Puligedda, Tomas Ondrejcak, Sharad Adekar, Cindy Chen, Pedro Cruz, Awilda Rosario, Sallie Macy, Alexandra J. Mably, Dominic M. Walsh, Ruben Vidal, Alan Solomon, Daniel Brown, Michael J Rowan, Todd Golde, and Scott Dessain (2015) A human monoclonal IgG that binds Aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo. Journal of Neuroscience 35:6265-76.
11. Ting Yang, Tiernan T. O’Malley, Daniel Kanmert, Jasna Jerecic, Lynn R. Zieske, Henrik Zetterberg, Bradley T. Hyman, Dominic M. Walsh and Dennis J. Selkoe (2015) A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human CSF. Alzheimer’s Research and Therapy 7: 14-30.
12. Alexandra J. Mably, Daniel Kanmert, Jessica M. Mc Donald, Wen Liu, Barbara J. Caldarone, Cynthia A. Lemere, Brian O’Nuallain, Kenneth S. Kosik and Dominic M. Walsh (2015) Tau immunization: a cautionary tale? Neurobiology of Aging 36:1316-32.
13. Alfred T. Welzel, John E. Maggio, Ganesh M. Shankar, Donald E. Walker, Beth L. Ostaszewski, Shaomin Li, Igor Klyubin, Michael J. Rowan, Peter Seubert, Dominic M. Walsh, and Dennis J. Selkoe (2014) Secreted amyloid b-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry. 53: 3908-21.
14. Igor Klyubin, Andrew Nicoll, Azadeh Khalili-Shirazi, Michael Farmer, Stephanie Canning, Alexandra J. Mably, Jackie Linehan, Alexander Brown, Madeleine Wakeling, Sebastian Brandner, Dominic M. Walsh, Michael J Rowan, and John Collinge (2014) Peripheral administration of a humanised anti-PrP antibody blocks Alzheimer’s disease Aβ synaptotoxicity. Journal of Neuroscience 34: 6140-5.
15. Hilla Fogel, Samuel Frere, Oshik Segev, Shashank Bharill, Ilana Shapira, Neta Gazit, Tiernan O’Malley, Edden Slomowitz, Yevgeny Berdichevsky, Dominic M. Walsh, Ehud Y. Isacoff, Joel A. Hirsch, Inna Slutsky (2014) APP homodimers transduce amyloid-β mediated increase in release probability at excitatory synapses. Cell Reports 7: 1560-76.
16. Judith J. Mittag, Silvia Milani, Dominic M. Walsh, Joachim O. Rädler, Jennifer J. McManus (2014) Simultaneous measurement of a range of particle sizes during Ab1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy. Biochemical and Biophysical Research Communications 448:195-9.
17. Christina R. Muratore, Heather C. Rice, Priya Srikanth, Dana G. Callahan, Taehwan Shin, Lawrence Benjamin, Dominic M. Walsh, Dennis J. Selkoe and Tracy L. Young-Pearse (2014) The familial Alzheimer’s disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Human Molecular Genetics 23: 3523-36.
18. Neng-Wei Hu, Andrew J. Nicoll, Dainan Zhang, Alexandra J. Mably, Tiernan O’Malley, Silvia A. Purro, Cassandra Terry, John Collinge, Dominic M. Walsh and Michael J. Rowan (2014) mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo. Nature Communications 4; 5: 3374.
19. Igor Klyubin, Tomas Ondrejcak, John Hayes, William K. Cullen, Alexandra J Mably, Dominic M Walsh, Michael J Rowan (2014) Neurotransmitter receptor and time dependence of the synaptic plasticity disrupting actions of Alzheimer’s disease Aβ in vivo. Philosophical Transactions of the Royal Society B: Biological Sciences 369: 20130147.
20. Monichan Phay, Veronika Blinder, Sallie Macy, Michael J. Greene, Daniel C. Wooliver, Wen Liu, Antoni Planas, Dominic M. Walsh, Lawreen H. Connors, Stanley R. Primmer, Sudhir Paul and Brian O’Nuallain (2014) TTR aggregate specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils. Rejuvenation Research 17: 97-104.
21. Charles Métais, Kathryn Brennan, Alex J. Mably, Michael Scott, Dominic M. Walsh and Caroline E. Herron (2014) Simvastatin treatment preserves synaptic plasticity in APPswe/ PS1dE9 mice. Journal of Alzheimer’s Disease 39: 315-29.
22. Andrew J. Nicoll, Silvia Panico, Darragh Freir, Daniel Wright, Cassandra Terry, Emmanuel Risse, Caroline E. Herron, Tiernan O’Malley, Jonathan D.F. Wadsworth, Mark A. Farrow, Dominic M. Walsh, Helen R. Saibil & John Collinge (2013) Amyloid-b nanotubes are associated with prion protein-dependent synaptotoxicity. Nature Communications. 4: 2416-25.
23. Kyongman An, Igor Klyubin, Youngkyu Kim, Jung Hoon Jung, Alexandra J Mably, Sean T O’Dowd, Timothy Lynch, Daniel Kanmert, Cynthia A Lemere, Gina M Finan, Joon Won Park, Tae-Wan Kim, Dominic M. Walsh, Michael J Rowan and Joung-Hun Kim (2013) Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo. Molecular Brain 6: 47-60.
24. Hon-Kit Wong, Tatiana Veremeyko, Nehal Patel, Cynthia A. Lemere, Dominic M. Walsh, Christine Esau, Charles Vanderburg and Anna M. Krichevsky (2013) De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer’s disease. Human Molecular Genetics 22: 3077-92.
25. Ting Yang, Soyon Hong, Tiernan O’Malley, Michael A. Farrell, Reisa A. Sperling, Dominic M. Walsh and Dennis J. Selkoe (2013) ELISAs with high specificity for soluble oligomers of amyloid ß-protein reveal natural Aß oligomers in human brain but not CSF. Alzheimer’s Disease & Dementia. 9: 99-112.
26. O’Dowd ST, Ardah MT, Johansson P, Lomakin A, Benedek GB, Roberts KA, Cummins G, El Agnaf OM, Svensson J, Zetterberg H, Lynch T, and Walsh DM. 2012. The ELISA-measured increase in CSF tau that discriminates Azlheimer’s disease from other neurodegenerative disorders is not attributable to differential recognition of tau assembly forms. Journal of Alzheimer’s Disease. 33: 923-8.
27. Cukalevski R, Boland B, Frohm B, Thulin E, Walsh DM and Linse S. 2012. Role of aromatic side chains in amyloid β-protein aggregation. ACS Chemical Neuroscience. 3: 1008-16.
28. Welzel AT, Williams AD, McWilliams-Koeppen HP, Acero L, Weber A, Blinder V, Mably A, Ehrlich HJ, Schwarz HP, Walsh DM, Solomon A and O’Nuallain B. 2012. Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide. PLoSOne. 7: eso317.
29. Moro ML, Giaccone G, Lombardi R, Indaco A, Uggetti A, Morbin M, Saccucci S, Di Fede G, Catanial M, Walsh DM, Demarchi A, Rozemuller A, Bogdanovic N, Bugiani O, Ghetti B, Tagliavini F. 2012. APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38. Acta Neuropathologica. 124: 809-21.
30. Borlikova GG, Trejo M, Mably AJ, Mc Donald JM, Sala Frigerio C, Regan CM, Murphy KJ, Masliah E and Walsh DM. 2012. Alzheimer brain-derived Aβ impairs synaptic remodelling and memory consolidation. Neurobiology of Aging. 34: 1315-1327.
31. Walsh DM, Teplow DB. 2012. Alzheimer’s disease and the amyloid β-protein. Progress in Molecular Biology and Translational Science. 107: 101-24.
32. Mc Donald J, Cairns NJ, Taylor-Reinwald L, Holtzman D, Walsh DM. 2012. The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer’s disease brain. Brain Research. 1450: 138-147.
33. Nicholson AM, Wold LA, Walsh DM and Ferreira A. 2012. β-amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons. Molecular Medicine. 27: 178-85.
34. O’Nuallain B, Klyubin I, McDonald JM, Barry A, Dykoski RK, Cleary JP, Gebbink M, Rowan MJ and Walsh DM. 2011. A Monoclonal Antibody Against Synthetic Aβ Dimers Assemblies Neutralizes Brain-Derived Synaptic Plasticity-Disrupting Aβ. Journal of Neurochemistry 2011; 119: 189-201.
35. Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez de Vega JM, Gruning B, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fandrich M, Frank RF, Reif B, Bunter S, Walsh DM and Wanker EE. 0211. An orcein-related small molecule promotes the conversion of toxic oligomers tonon-toxic, β-sheet-rich amyloid fibrils. Nature Chemical Biology; 8: 93-101.
36. Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J. 2011. Interaction between prion protein and toxic Aβ assemblies can be therapeutically targeted at multiple sites. Nature Communications. 2: 1341-51.
37. Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wullner U, Glebov K, Heneka MT, Walsh DM, Azeckstetter M and Walter J. 2011. Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer’s disease. EMBO Journal; 30: 7259-63.
38. Barry AE, Klyubin I, Mc Donald JM, Mably AJ, Farrell MA, Scott M, Walsh DM and Rowan MJ. Alzheimer’s disease brain-derived Aβ-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. Jounal of Neuroscience 2011; 31: 7259-63.
39. Jin M, Shepardson N, Yang T, Walsh DM and Selkoe DJ. Soluble Amyloid β-Protein Dimers Isolated from alzheimer Cortex Directly Induce Tau Hyperphosphorylation and Neuritic Degeneration. Proceedings of the National Academy of Science (USA) 2011; 108: 5819-24.
40. Boland B, Smith DA, Jung SS, Mooney D, Walsh DM, Platt FM. Macroautophagy is Not Directly Involved in the Metabolism of Amyloid Precursor Protein. Journal of Biological Chemistry 2010; 285: 37415-26.
41. O’Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J and Walsh DM. Aβ dimers rapidly form stable synaptotoxic protofibrils. Journal of Neuroscience 2010; 30: 14411-19.
42. McDonald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG and Walsh DM. The presence of SDS-stable Aβ dimers is strongly associated with Alzheimer-type dementia. Brain 2010; 133: 1297-1311.
43. Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, and Regan CM. Cell-derived Aβ oligomers inhibit synapse remodeling necessary for memory consolidation. Neurobiology of Aging in press (2010 Jan 22. Epub ahead of print).
44. Reed MN, Hofmeister JJ, Jungbauer L, Welzel AT, Yu C, Shearman MJ, Lesné S, LaDu M, Walsh DM, Ashe KH, and Cleary JP. Cognitive Effects of Naturally and Synthetically Derived Ab Oligomers. Neurobiology of Aging 2010; 32: 1784-94. (Epub 2010 Jan 19).
45. Hampel H, Shen Y, Walsh DM, Aisen P, Shaw L, Zetterberg H, Trojanowski J, and Blennow K. (2010) Biological markers of β-amyloid related mechanisms in Alzheimer’s Disease. Experimental Neurology2010; 223: 334-46.
46. Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Stufenbiel M, Paganetti P, Selkoe DJ and Walsh DM. β-secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. FEBS Journal 2010; 277: 1503-18.
47. Hellstrand E, Boland B, Walsh DM, Linse S. An improved method for monitoring Aβ aggregation produces highly reproducible data indicative of non-stochastic nucleation and a two-phase process. 2010. ACS Neuroscience; 1: 13-18.
48. Sala Frigerio C, Kukar TL, Engel PC, Golde TE and Walsh DM. An NSAID-like compound, FT-9, preferentially inhibits ϒ-secretase cleavage of APP compared to its effect on APLP1. Biochemistry 2009;48, 10894-10904.
49. Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA and Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer’s disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life. Neurobiology of Disease 2009; 36: 293-302.
50. Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM and Selkoe DJ. Soluble Aβ oligomers facilitate hippocampal long-term depression by disrupting glutamate uptake at the synapse. Neuron 2009; 62: 788-801.
51. Shankar GM, Walsh DM. Alzheimer’s disease: synaptic dysfunction and Abeta. Mol Neurodegener. 2009; 4:48.
52. Minogue AM, Stubbs AK, Sala Frigerio C, Fadeeva JV, Boland B, Tang J and Walsh DM. ϒ-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Research 2009; 1262: 89-99.
53.Walsh DM, Thulin E, Minogue AM, Gustavsson N, Linse S. A facile method for the expression and purification of the Alzheimer disease-associated amyloid β-peptide. FEBSJ 2009; 276: 1266-81.
54. Xia W, Yang T, Smith IM, Shen Y, Walsh DM and Selkoe DJ. A specific ELISA for measuring amyloid β-protein oligomers in human plasma and the brains of Alzheimer patients. Archieves in Neurology 2009; 66: 1-10.
55. Hu N, Smith IM, Walsh DM and Rowan MJ. Soluble amyloid-ß peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo. Brain 2008; 131: 2414-24.
56. Cabaleiro-Lago C, Quinlan-Pluck F, Lynch I, Lindan S, Minogue AM, Thulin E, Walsh DM, Dawson KA, Linse S. Inhibition of amyloid β-protein fibrillation by polymeric nanoparticles. Journal of American Chemical Society 2008; 130: 15437-43.
57. O’Shea SD, Smith IM, McCabe OM, Cronin MM, Walsh DM and O’Connor WT. 2008. Intracerebroventribular administration of amyloid β-protein oligomers selectively increases dorsal hippocampal dialysate glutamate levels in the awake rat. Sensors; 8: 7428-37.
58. Irvine GB, El-Agnaf OM, Shankar GM, Walsh DM. Protein aggregation in the brain: the molecular basis for Alzheimer’s and Parkinson’s diseases. Mol Med. 2008 Jul-Aug; 14(7-8):451-64.
59. Betts V, Leissring MA, Keck S, Dolios G, Wang R, Selkoe DJ and Walsh DM. Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin. Neurobiology of Disease 2008; 31: 442-50.
60. Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Welzel AT, Price RW, Eriksen J, Jansen-West K, Cottrell BA, Verbeeck C, Schmidt B, Wolfe MS, Fauq A, Walsh DM, Koo EH, Golde TE. Substrate targeting by g-Secretase Modulators. Nature 2008; 453: 925-29.
61. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith IM, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL and Selkoe DJ. Amyloid-ß oligomers isolated directly from the brains of Alzheimer disease patients potently impair synaptic structure and plasticity and learned behavior. Nature Medicine 2008; 14: 837-42.
62. Klyubin I, Betts V, Welzel A, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R,Walsh DM and Rowan MJ. Aß dimers in human cerebrospinal fluid disrupt synaptic plasticity: prevention by systemic passive immunization. Journal of Neuroscience 2008; 28: 4231-37.
63. McDonough SM, Liddle SD, Hunter R, Walsh DM, Glasgow P, Gormley G, Hurley D, Delitto A, Park J, Bradbury I, Baxter GD. Exercise and manual auricular acupuncture: a pilot assessor-blind randomised controlled trial. (The acupuncture and personalised exercise programme (APEP) trial). BMC Musculoskelet Disord. 2008; 9:31.
64. Farris W, Schütz S, Cirrito JR, Shankar GM, Sun X, May PC, George A, Leissring MA, Walsh DM, Qiu WQ,Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and precipitates cerebral amyloid angiopathy. Amercian Journal of Pathology 2007; 171: 241-51.
65. Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ. The APP family of proteins: similarities and differences. Biochem Soc Trans. 2007 Apr; 35(Pt 2):416-20.
66. Walsh DM, Finwall J, Touchette PE, McGregor MR, Fernandez GE, Lott IT, Sandman CA. Rapid assessment of severe cognitive impairment in individuals with developmental disabilities. J Intellect Disabil Res. 2007 Feb; 51(Pt 2):91-100.
67. Shankar GM, Townsend M, Walsh DM, Selkoe DJ and Sabatini BL. Natural oligomers of the Alzheimer amyloid-β protein lower dendritic spine density and synapse number in hippocampus. Journal of Neuroscience 2007; 27: 2866-75.
68. Walsh DM, Selkoe DJ. A beta oligomers – a decade of discovery. J Neurochem. 2007 Jun; 101(5):1172-84.
69. Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007 Mar 14; 27(11):2866-75.
70. Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O’Hare E, Walsh DM and Selkoe DJ. An orally available compound prevents deficits in hippocampal long-term potentiation and memory caused by soluble oligomers of the Alzheimer amyloid β-protein. Annals of Neurology 2006; 60: 668–676.
71. Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, Wetzel R, Wexler NS, Young AB, Bain L. Common threads in neurodegenerative disorders of aging. Alzheimers Dement. 2006 Oct; 2(4):322-6.
72. Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret J-M, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M. Exogenous induction of Aβ-amyloidogenesis is governed by intrinsic properties of agent and host. Science 2006. 313: 1781-84.
73. Townsend M, Shankar GM, Mehta T, Walsh DM and Selkoe DJ. The effects of secreted oligomers of the amyloid β-protein on hippocampal plasticity: a role for trimers. Journal of Physiology 2006; 15: 477-92.
74. Walsh DM, Townsend M, Podlisny MB, Ganesh M. Shankar GM, Fadeeva JV, Agnaf OE, Hartley DM and Selkoe DJ. Certain inhibitors of synthetic Aβ fibrillogenesis block oligomerization of natural Aβ and thereby rescue long term potentiation. Journal of Neuroscience 2005; 25: 2455-62.
75. Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ and Rowan MJ. Active and passive immunotherapy for Alzheimer’s disease: direct neutralization of in vivo synaptic plasticity disrupting amyloid β-protein oligomers. Nature Medicine 2005; 11: 556-61.
76. Cleary J, Walsh DM, Hofmeister J, Shankar GV, Selkoe DJ, Ashe KH. Oligomers but not monomers of the amyloid ß protein transiently disrupt learned behavior. Nature Neuroscience 2005; 8: 79-84.
77. Seabrook TJ, Bloom JK, Iglesias M, Spooner ET, Walsh DM, Lemere CA. Human or rodent amyloid β results in a peptide specific immune response in APP-tg and wildtype mice. Neurobiology of Disease 2004; 25: 1141-51.
78. Ye CP, Walsh DM, Vassilev PM, Selkoe DJ, and Hartley DM. Protofibrillar amyloid β-protein induce acute electrophysiological changes in cortical neurons: NMDA vs. Non-NMDA. Neuroscience Letters 2004; 366: 320-325.
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